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KMID : 0361520100210040173
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Korean Journal of Psychopharmacology
2010 Volume.21 No. 4 p.173 ~ p.182
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Is Tianeptine in a Class of Its Own?
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Woo Young-Sup
Bahk Won-Myong
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Abstract
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Tianeptine is an antidepressant effective in reducing depressive symptoms and combined anxiety symptoms. Tianeptine has drawn much attention, because this compound challenges traditional monoaminergic hypothesis of depression. The involvement of glutamate in the mechanism of action of tianeptine is consistent with glutamate hypothesis of depression which demonstrating the key function of glutamate in the mechanism of altered neuroplasticity that underlies the symptoms of depression. This article reviews the evidence of tianeptine’s mechanism of action with a focus on the glutamatergic system in an attempt to provide a possible explanation for the observed beneficial clinical profile of tianeptine in patients with depression.
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KEYWORD
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Tianeptine, Depression, Glutamate, Neuroplasticity
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